NAD Plus
NAD Plus Japanese Extract
The coenzyme your cells run on — paired with a senolytic and a sirtuin activator.
- 500 mg NAD+ direct — the coenzyme behind cellular energy + DNA repair
- Quercetin senolytic — clears the cells that suppress NAD+
- 98% resveratrol — fires the SIRT1/SIRT3 longevity pathways
- Three declared doses — no proprietary blend, synergistic by design
NAD+ runs cellular energy and DNA repair — and falls with age. This pairs 500 mg direct NAD+ with a quercetin senolytic and 98% resveratrol, every dose declared.
Flat energy and slow recovery that sleep never quite fixes — often NAD+ depletion at the mitochondria. This rebuilds the substrate directly, at a declared 500 mg.
NAD+ runs the electron transport chain every mitochondria depends on. Levels drop ~50% from 20 to 60 — this restores the substrate directly.
Senescent cells secrete inflammation that suppresses NAD+ metabolism. Quercetin selectively clears them — confirmed in human tissue within days.
For people who read Sinclair and check Examine before buying — and wanted three peer-reviewed mechanisms, not one podcast molecule.
Peer-reviewed signals across NAD+ metabolism, senescent cell clearance, and resveratrol longevity pathways — mechanism, not category marketing.
Three actives, three mechanisms, every dose declared. No blend, nothing hidden.
Three compounds. Three distinct roles. One upstream target.
NAD+ shuttles electrons through the mitochondrial chain and fuels PARP DNA-repair and sirtuins. Age depletes all three — supplementing restores the substrate.
Senescent cells secrete SASP factors that suppress NAD+ synthesis. Quercetin triggers apoptosis in them while sparing healthy tissue.
Resveratrol activates sirtuins — and they require NAD+ as co-substrate, so the pairing is synergistic. Knotweed at 98% is the purest plant source.
Energy substrate stabilises first — the afternoon crash flattens, output smooths. Some notice deeper sleep.
Senolytic and sirtuin axes compound. Training recovery improves; the silent inflammatory background quiets.
The longevity substrate settles at a higher baseline — sustained energy, sharper cognition, a raised mitochondrial floor.
Long-game territory. NAD+ decline is ongoing, so replenishment should be too — a protocol layer, not a cycle.
Typical, compound-based expectation — not medical advice. Individual response varies.
Two capsules daily with water — preferably with a meal. Morning is the default (NAD+ feeds daytime energy metabolism). If stacking with CoQ10 (SL-06), take together: they address adjacent parts of the same mitochondrial system. Consistent daily use matters more than timing precision.
Peer-reviewed. On the three actives.
1,000 mg/day NR raised blood NAD+ ~60% vs placebo over 6 weeks in a double-blind crossover RCT (n=30, aged 55–79) — no serious adverse events.
Trammell SAJ et al. Nat Commun. 2016;7:12948 ↗12-week RCT (n=36): 250 mg/day NMN significantly raised NAD+ metabolome markers and reduced arterial stiffness — the first clinical link between NAD+ restoration and a cardiovascular gain.
Morita Y et al. Sci Rep. 2023;13:2786 ↗First human senolytic trial: D+Q cleared senescent-cell burden in adipose tissue within 11 days, with drops in SASP factors IL-6 and MMP-9/12 — quercetin’s mechanism, confirmed in vivo.
Xu M et al. EBioMedicine. 2018;47:446–456. PMC6796530 ↗200 mg/day for 26 weeks improved word recall and hippocampal connectivity vs placebo in older adults (n=46), and lowered HbA1c — consistent with SIRT1 engagement.
Witte AV et al. J Neurosci. 2014;34(23):7862–70 ↗read lifespan last year, wanted something peer-reviewed to act on — not nmn because a podcast said so. nad+ direct plus quercetin and resveratrol, the three the literature points to. 10 weeks in, steadier output, less fade by 3pm. doses on the box.
already running coq10, added this for the sirtuin layer. first 2 weeks nothing. week 5, recovery between sessions noticeably faster. resting HR dropped 3bpm over 8 weeks — i track it. something shifted.
bought it for the quercetin specifically — read the mayo senolytic data. 250mg from sophora is the only consumer form with evidence. 8 weeks in, crp on bloodwork is down. minus a star because i'm not religious about causation.
three actives, three doses, no blend hiding anything. quercetin from sophora (real standardised source), 98% resveratrol from knotweed, nad+ 500mg declared. 6 weeks in, energy floor feels higher — not stimulant, just less deficit by afternoon.
six weeks, then stopped 10 days waiting on restock. only then noticed — the 2am wake-ups came back, the afternoon drag returned. sometimes you know it works when it stops. back on. want another 12 weeks before 5 stars.
ex-gym bro who does his homework now. nad+ depletion is textbook, quercetin senolytic is proven in human tissue, resveratrol sirt1 is in nature and j neurosci. first longevity product i could verify before taking. 7 weeks, recovery and cognition both moved.